Research & Development

Circulating Palmitoleate Strongly and Independently Predicts Insulin Sensitivity
Norbert Stefan; Konstantinos Kantartzis; Nora Celebi; Harald Staiger; Jürgen — Diabetes Care; Feb 2010;

~ “Circulating palmitoleate strongly and independently predicts insulin sensitivity, suggesting that it plays an important role in the pathophysiology of insulin resistance in humans.” Read more… 

Chronic administration of palmitoleic acid reduces insulin resistance and hepatic lipid accumulation in KK-Ay Mice with genetic type 2 diabetes

Zhi-Hong Yang, Hiroko Miyahara and Akimasa Hatanaka

~ “Studies have demonstrated the beneficial effect of palmitoleic acid (C16:1 n-7) on reducing muscle insulin resistance and preventing beta-cell apoptosis. However, the effect of palmitoleic acid on diabetes remains to be elucidated. The aim of this study was to examine the antidiabetic effect of palmitoleic acid in KK-Ay mice, a spontaneous model for studies of obese type 2 diabetes with low insulin sensitivity.”  Read more…

Effects of eicosapentaenoic acid on the early stage of type 2 diabetic nephropathy in KKAy/Ta mice: involvement of anti-inflammation and antioxidative stress

Minfang Zhanga, Shinji Hagiwaraa, Masukazu Matsumotoa, Leyi Gub, Mitsuo Tanimotoa, Shinji Nakamuraa, Shigeru Kanekoa, Tomohito Gohdaa, Jiaqi Qianb, Satoshi Horikoshia, Yasuhiko Tominoa

~ “Eicosapentaenoic acid (EPA) has been reported to have beneficial effects on the progression of various renal diseases including diabetic nephropathy; however, the precise mechanisms are not completely understood.” Read more…

Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism

Haiming Cao, Kristin Gerhold, Jared R. Mayers, Michelle M. Wiest, Steven M. Watkins, and Gokhan S. Hotamisligil

~ “Foundational study that proved that out of 400 screened fatty acids, palmitoleate was determined to be the regulator “lipokine” that influenced fatty liver deposition/production, potentiated insulin action, directly counteracted the negative  effects of palmitate, inhibited SCD1 and FAS (fatty acid synthase).  Their new term at the time, “lipokine” indicated that this compound acted as a hormone.” Read more…

Trans-Palmitoleic Acid, Metabolic Risk Factors, and New-Onset Diabetes in U.S. Adults, A Cohort Study

Dariush Mozaffarian, MD, DrPH; Haiming Cao, PhD; Irena B. King, PhD; Rozenn N. Lemaitre, PhD, MPH; Xiaoling Song, PhD;
David S. Siscovick, MD, MPH; and Go¨ khan S. Hotamisligil, MD, PhD

~ “Circulating trans-palmitoleate is associated with lower insulin resistance, presence of atherogenic dyslipidemia, and  incident diabetes.”  Read more…

A Research Comparison of Fatty Acids – EPA and Palmitoleic Acid

~ “Palmitoleic Acid (PA) Outperforms EPA in Identical KK-Aʸ Mouse Study Regarding Effects on Triglyceride Levels and Weight Gain” Read more…

Harvard Study
~ “Listen to a podcast interview with Harvard researcher Dr. Gokhan Hotamisligil suggesting  that an Omega 7 dietary supplement could stimulate insulin action to combat diabetes.”

Structure Activity Relationships (SARs) Among Fatty Acids
Implications for Differential Toxicity Associated with Palmitic Acid

“Fatty acids as a group have historically been classified as possessing identical properties and from the broad health standpoint have been believed to hold negative implications toward societal outcome and disease. In essence, it has been believed that ‘one fatty acid is the same as another’”. Read more…