Scientific Research on Omega-7

Safety of Palmitoleic Acid

Nancy Morse

A toxicty/safety assessment of dietary palmitoleic acid (POA). Read more…

Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism

Haiming Cao, Kristin Gerhold, Jared R. Mayers, Michelle M. Wiest, Steven M. Watkins, and Gokhan S. Hotamisligil, Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA

Foundational study that proved that out of 400 screened fatty acids, palmitoleate was determined to be the regulator “lipokine” that influenced fatty liver deposition/production, potentiated insulin action, directly counteracted the negative effects of palmitate, inhibited SCD1 and FAS (fatty acid synthase).  Their new term at the time, “lipokine” indicated that this compound acted as a hormone. A hormone (such as insulin) characteristically promotes a cascade of effects out of proportion to its concentration – meaning, it magnifies multiple effects downstream at very low concentrations.  The counteracting effects against the “bad fatty acid” of palmitate corroborates other findings from other investigators.  The fact that it promotes insulin action leads to the conclusion that it could indeed be effective in promoting insulin sensitivity, later proven by the Japanese work. The inhibition of SCD1 is also in line with a possible weight loss action, as well as the inhibition of FAS, which follows along the same lines. Read more…

Serum Lipid Effects of a High-Monounsaturated Fat Diet Based on Macadamia Nuts

J. David Curb, MD; Gilbert Wergowske, MD; Joan C. Dobbs, PhD; Robert D. Abbott, PhD; Boji Huang, MD, PhD

The study by Curb on the effects of macadamia nuts on serum lipid values in humans demonstrated an increase in HDL and a decrease in total cholesterol and LDL.  These results, especially on HDL, parallel the work done at Penn State, also using macadamia nuts.  Macadamia nuts are the highest-palmitoleic acid-containing natural substances in the nut family, and probably every other natural source as well.  It proves that Omega 7 Palmitoleic Acid has such actions as well. Read more…

Oral administration of omega-7 palmitoleic acid induces satiety and the release of appetite-related hormones in male rats

Zhi-Hong Yang ⇑, Jiro Takeo, Masashi Katayama

Obesity is a growing problem around the world, representing a metabolic disorder that is associated with many severe, lifestyle related diseases including cardiovascular disease, diabetes, hypertension, hyperlipidemia, and hyperuricemia (Friedman & Andrus, 2012; Van Gaal, Mertens, & De Block, 2006). A stable body weight is maintained by balancing energy intake and energy expenditure. As such, excessive energy intake is an established risk factor for developing obesity (Burkhalter & Hillman, 2011). Hunger and satiety are physiologically important in this context because they regulate energy intake. It is entirely conceivable, therefore, that appetite suppression represents an effective means of reducing energy intake. Read more…

Chronic administration of palmitoleic acid reduces insulin resistance and hepatic lipid accumulation in KK-Ay Mice with genetic type 2 diabetes

Zhi-Hong Yang, Hiroko Miyahara and Akimasa Hatanaka

This was the first time that palmitoleic acid was administered exogenously, with the effects being measured. All previous work – including Harvard’s work by Cao – assessed palmitoleate values as a result of dietary ingestion and not from what would be therapeutic doses. This is key because now the effects can be reproduced with possible ingestion of something like a gel cap containing palmitoleic acid or its ester form.  Read more…

“Lipid hormones produced by fat [...] may help to keep you thin…” ~ a Harvard Study

Listen to a podcast interview with Harvard researcher Dr. Gokhan Hotamisligil suggesting that an Omega 7 dietary supplement could stimulate insulin action to combat diabetes.

Distinct Effects of Saturated and Monounsaturated Fatty Acids on β-Cell > Turnover and Function

 K. Maedler, G.A. Spinas, D. Dyntar, W. Moritz, N. Kaiser, and Marc Y. Donath

This paper corroborates the beneficial effects of palmitoleate on beta cell function and longevity, directly counteracting the bad effects of palmitic acid. This “bad fatty acid”, which exists in almost double concentration to Omega 7 from places like sea buckthorn. Palmitic acid has universally been shown to be negative in many, many publications and it is uncontroversial. Read more…

Circulating Palmitoleate Strongly and Independently Predicts Insulin Sensitivity in Humans

 Norbert Stefan MD, Konstantinos Kantartzis MD, Nora Celebi MD, HaraldStaiger PHD, Jurgen Machann PHD, Fritz Schick MD-PHD, Elexander Cegan PHD,Michaela Elcnerova PHD, Erwin Schleicher PHD, Andreas Fritsche MD and Hans-Ulrich Haring MD.

This study correlates insulin sensitivity increases with palmitoleate concentrations, and proves there is something special about Omega 7 Palmitoleic Acid. Read more…

Purified Omega 7 Palmitoleic Acid

Why Provinal™ Ultrapurified Omega 7 is the best source for Palmitoleic Acid

Dr. Jeffrey Green, Director of Research and Development Tersus Pharmaceuticals

Fatty acids as a group have historically been classified as possessing identical properties and from the broad health standpoint have been believed to hold negative implications toward societal outcome and disease. In essence, it has been believed that “one fatty acid is the same as another”. Read more…